Substance P
Educational resource. Not medical advice. No dosing or instructions.
Safety grade
5/10
Moderate
Also known as
substance psubstance-psubstancep
AA sequence
Not available yet.
No overview has been added yet.
Why people are interested in this peptide and how it is commonly discussed in real-world wellness, rehabilitation, and athletic communities.
Why people are interested
- Pep-Talk curation pending: we’re reviewing the evidence and will expand this section soon.
- general recovery and resilience interest (anecdotal)
- common biohacker curiosity due to community reports
- interest in mechanisms suggested by early evidence
- used in goal-based stacking discussions (anecdotal)
- exploration in wellness communities despite evidence limits
Use cases (real-world)
These are the most common real-world reasons people look into this peptide, plus the context that tends to matter most (quality, expectations, and safety).
research relevance in pain and neuroinflammation pathways
physiology relevance in nausea and sensory signaling
often mentioned in inflammation/pain discussions (claims can be speculative)
Substance P is a neuropeptide involved in pain signaling, inflammation, and nausea pathways. It is not a wellness peptide; altering neuroimmune signaling outside research can carry real risk.
Common reasons people consider it
- research relevance in pain and neuroinflammation pathways
- physiology relevance in nausea and sensory signaling
- often mentioned in inflammation/pain discussions (claims can be speculative)
Most commonly reported downsides
- flushing or warmth
- headache
- nausea
- lightheadedness
Rare but important symptoms to watch for
These are uncommon, but if they occur, stop and seek medical care.
- severe shortness of breath or wheezing
- fainting or collapse
- severe allergic reaction symptoms (hives, facial swelling, trouble breathing)
Who should be cautious
- people with asthma or airway reactivity
- people with significant cardiovascular disease or frequent fainting
- pregnant or breastfeeding individuals
- adolescents (high consequence plus inappropriate for non-clinical use)
Interactions summarize known or plausible ways this peptide may intersect with medications, supplements, or physiologic states. Use this as a risk-awareness map: what to ask about, what to watch for, and what deserves a clinician conversation.
Interaction summary
Interactions here are category flags — they’re meant to help you ask better questions and avoid obvious conflicts. They are not a dosing guide.
Drug-class flags to review:
neuropeptide-cns-context
If you’re on cardiovascular, anticoagulant/antiplatelet, serotonergic, or immunomodulating meds/supplements, treat uncertainty as a reason to slow down and verify with a clinician.
Medication classes
Supplement classes
None
Other peptides
None
Developmental risk is flagged due to limited adolescent data and uncertain long-term effects. Endocrine, growth, neurodevelopmental, and metabolic setpoints may be sensitive to perturbation. This section is descriptive only; uncertainty is explicitly acknowledged.
No curated human clinical sources have been added yet.
Pep-Talk curation pending: we’re reviewing the evidence and will expand this section soon.
Pep-Talk is informational only and not medical advice. We make no warranties and are not liable for actions you take. You are responsible for your decisions and outcomes.
Community notes
Educational discussion only. No dosing, protocols, schedules, or instructions. Submissions are moderated before appearing.
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