Selank
Educational resource. Not medical advice. No dosing or instructions.
Safety grade
5/10
Moderate
Also known as
selank
AA sequence
Not available yet.
What it is
Selank is a synthetic peptide based on tuftsin-related sequences, developed to influence neuromodulatory pathways relevant to anxiety and cognition. Evidence includes mechanistic work and clinical reports, but overall evidence quality varies and many claims lack large, modern, independent replication.
Why people are interested in this peptide and how it is commonly discussed in real-world wellness, rehabilitation, and athletic communities.
Why people are interested
- a synthetic peptide based on tuftsin-related sequences, developed to influence neuromodulatory pathways relevant to anxiety and cognition
- evidence includes mechanistic work and clinical reports, but overall evidence quality varies and many claims lack large, modern, independent replication
- general recovery and resilience interest (anecdotal)
- common biohacker curiosity due to community reports
- interest in mechanisms suggested by early evidence
- used in goal-based stacking discussions (anecdotal)
- exploration in wellness communities despite evidence limits
Selank is discussed as a calming, anxiety-oriented nootropic peptide. Human evidence is limited and effects vary widely by person. The main real-world risk is treating it as a substitute for clinical care or relying on unregulated sourcing.
Common reasons people consider it
- calmer baseline mood / reduced anxious feeling (community-reported)
- stress tolerance support during high-pressure periods (community-reported)
- sleep continuity support in people whose sleep is disrupted by anxiety (community-reported)
- cognitive steadiness under stress (community-reported)
Most commonly reported downsides
- headache
- fatigue or “flat” feeling
- nausea or stomach upset
- irritability or mood shift
Rare but important symptoms to watch for
These are uncommon, but if they occur, stop and seek medical care.
- severe allergic reaction symptoms (hives, facial swelling, breathing difficulty)
- marked mood destabilization (panic escalation, agitation, suicidal thoughts)
Who should be cautious
- people with severe anxiety, panic disorder, bipolar disorder, or major depression
- people taking psychiatric medications (coordinate with a clinician; avoid abrupt changes)
- pregnancy or breastfeeding
- anyone with a history of serious allergic reactions to peptides
Interactions summarize known or plausible ways this peptide may intersect with medications, supplements, or physiologic states. Use this as a risk-awareness map: what to ask about, what to watch for, and what deserves a clinician conversation.
Medication classes
Supplement classes
None
Other peptides
None
Developmental risk is flagged due to limited adolescent data and uncertain long-term effects. Endocrine, growth, neurodevelopmental, and metabolic setpoints may be sensitive to perturbation. This section is descriptive only; uncertainty is explicitly acknowledged.
REVIEW · Grade: human_observational · Year: 2025
Benefits of alanyl-glutamine and omega-3 PUDAs in postoperative gastroduodenal perforation patients: A single-center retrospective study.
Region-specific and heterogeneous; use for boundaries, not claim inflation.
JOURNAL_ARTICLE · Grade: animal · Year: 2015
[Optimization of the treatment of anxiety disorders with selank].
Supports mechanism discussion only; not proof of human benefit.
Not FDA-approved. Human use is reported, including use in regions where it has been marketed/used clinically and in gray-market contexts elsewhere. Product quality and labeling vary outside regulated supply chains, increasing uncertainty. Classification describes what Selank is and the general domain where it appears.
Pep-Talk is informational only and not medical advice. We make no warranties and are not liable for actions you take. You are responsible for your decisions and outcomes.
Community notes
Educational discussion only. No dosing, protocols, schedules, or instructions. Submissions are moderated before appearing.
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