Mots C
Educational resource. Not medical advice. No dosing or instructions.
Safety grade
5/10
Moderate
Also known as
motscmots cmots-c
AA sequence
Not available yet.
What it is
What it is and why it is studied are summarized here in a conservative, evidence-bounded way.
Why people are interested in this peptide and how it is commonly discussed in real-world wellness, rehabilitation, and athletic communities.
Why people are interested
- studied are summarized here in a conservative, evidence-bounded way
- general recovery and resilience interest (anecdotal)
- common biohacker curiosity due to community reports
- interest in mechanisms suggested by early evidence
- used in goal-based stacking discussions (anecdotal)
- exploration in wellness communities despite evidence limits
Use cases (real-world)
These are the most common real-world reasons people look into this peptide, plus the context that tends to matter most (quality, expectations, and safety).
metabolic health curiosity (early-stage evidence)
exercise tolerance and recovery discussions (mixed, often overstated)
sometimes discussed for insulin sensitivity themes (uncertain outcomes)
MOTS-c is discussed for metabolic health and exercise performance themes, often framed as “mitochondrial support.” Human evidence is limited, so expectations should be conservative.
Common reasons people consider it
- metabolic health curiosity (early-stage evidence)
- exercise tolerance and recovery discussions (mixed, often overstated)
- sometimes discussed for insulin sensitivity themes (uncertain outcomes)
Most commonly reported downsides
- headache
- nausea
- fatigue
Rare but important symptoms to watch for
These are uncommon, but if they occur, stop and seek medical care.
- severe allergic reaction symptoms (hives, facial swelling, trouble breathing)
- chest pain, fainting, or severe shortness of breath
Who should be cautious
- people with diabetes or unstable blood sugar control
- people with significant cardiovascular disease
- pregnant or breastfeeding individuals
- adolescents (limited human evidence and endocrine/metabolic uncertainty)
Interactions summarize known or plausible ways this peptide may intersect with medications, supplements, or physiologic states. Use this as a risk-awareness map: what to ask about, what to watch for, and what deserves a clinician conversation.
Interaction summary
Interactions here are category flags — they’re meant to help you ask better questions and avoid obvious conflicts. They are not a dosing guide.
Drug-class flags to review:
diabetes-glucose-lowering
If you’re on cardiovascular, anticoagulant/antiplatelet, serotonergic, or immunomodulating meds/supplements, treat uncertainty as a reason to slow down and verify with a clinician.
Medication classes
Supplement classes
None
Other peptides
None
Developmental risk is flagged due to limited adolescent data and uncertain long-term effects. Endocrine, growth, neurodevelopmental, and metabolic setpoints may be sensitive to perturbation. This section is descriptive only; uncertainty is explicitly acknowledged.
JOURNAL_ARTICLE · Grade: animal · Year: 2015
A 16-amino-acid peptide named MOTS-c regulates insulin sensitivity and metabolic homeostasis
Discovery/characterization (animal + cellular). Mechanism framing only.
JOURNAL_ARTICLE · Grade: animal · Year: 2021
MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis
Animal study; does not establish human efficacy.
JOURNAL_ARTICLE · Grade: human_observational · Year: 2021
Effect of aerobic and resistance exercise on the mitochondrial-derived peptide MOTS-c (human observational biomarker context)
Human observational/biomarker context; not proof of clinical benefit.
REVIEW · Year: 2023
MOTS-c: A promising mitochondrial-derived peptide (review)
Review synthesis; use for uncertainty boundaries.
REVIEW · Year: 2022
MOTS-c, the Most Recent Mitochondrial Derived Peptide (review)
Review synthesis; not proof of efficacy.
This entry summarizes how the compound is discussed/used in the real world without endorsing use or providing instructions. Classification describes what MOTS-c is and the general domain where it appears.
Pep-Talk is informational only and not medical advice. We make no warranties and are not liable for actions you take. You are responsible for your decisions and outcomes.
Community notes
Educational discussion only. No dosing, protocols, schedules, or instructions. Submissions are moderated before appearing.
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