Endothelin-1
Educational resource. Not medical advice. No dosing or instructions.
Safety grade
5/10
Moderate
Also known as
et-1et1endothelinendothelin 1endothelin-1endothelin1
AA sequence
Not available yet.
No overview has been added yet.
Why people are interested in this peptide and how it is commonly discussed in real-world wellness, rehabilitation, and athletic communities.
Why people are interested
- Pep-Talk curation pending: we’re reviewing the evidence and will expand this section soon.
- general recovery and resilience interest (anecdotal)
- common biohacker curiosity due to community reports
- interest in mechanisms suggested by early evidence
- used in goal-based stacking discussions (anecdotal)
- exploration in wellness communities despite evidence limits
Endothelin-1 is a vasoconstrictor involved in blood pressure regulation and vascular disease biology. It is not a wellness peptide; non-medical use is high-risk.
Common reasons people consider it
- physiology relevance in vascular tone regulation
- research relevance in pulmonary hypertension and cardiovascular disease pathways
Most commonly reported downsides
- headache
- blood pressure changes (often felt as head pressure or dizziness)
- nausea
Rare but important symptoms to watch for
These are uncommon, but if they occur, stop and seek medical care.
- severe chest pain, severe shortness of breath, or collapse
- dangerous blood pressure symptoms (confusion, fainting)
- severe allergic reaction symptoms (hives, facial swelling, trouble breathing)
Who should be cautious
- people with cardiovascular disease, pulmonary hypertension, or stroke history
- people with uncontrolled hypertension
- pregnant or breastfeeding individuals
- adolescents (high consequence plus inappropriate for non-clinical use)
Interactions summarize known or plausible ways this peptide may intersect with medications, supplements, or physiologic states. Use this as a risk-awareness map: what to ask about, what to watch for, and what deserves a clinician conversation.
Medication classes
Supplement classes
None
Other peptides
None
Developmental risk is flagged due to limited adolescent data and uncertain long-term effects. Endocrine, growth, neurodevelopmental, and metabolic setpoints may be sensitive to perturbation. This section is descriptive only; uncertainty is explicitly acknowledged.
No curated human clinical sources have been added yet.
Pep-Talk curation pending: we’re reviewing the evidence and will expand this section soon.
Pep-Talk is informational only and not medical advice. We make no warranties and are not liable for actions you take. You are responsible for your decisions and outcomes.
Community notes
Educational discussion only. No dosing, protocols, schedules, or instructions. Submissions are moderated before appearing.
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