Aod-9604
Educational resource. Not medical advice. No dosing or instructions.
Safety grade
4/10
Moderate
Also known as
aodhGH fragment 176-191aod 9604aod-9604aod9604fragment 176 191fragment 176-191hgh fragment 176 191hgh fragment 176-191
AA sequence
YLRIVQCRSVEGSCGF
What it is
AOD-9604 is a synthetic peptide derived from amino acids 176–191 of human growth hormone. It was developed to isolate the lipolytic (fat-metabolizing) effects of hGH without stimulating growth or insulin-like growth factor pathways.
Why people are interested in this peptide and how it is commonly discussed in real-world wellness, rehabilitation, and athletic communities.
Why people are interested
- a synthetic peptide derived from amino acids 176–191 of human growth hormone
- it was developed to isolate the lipolytic (fat-metabolizing) effects of hGH without stimulating growth or insulin-like growth factor pathways
- weight-loss support (commonly discussed)
- metabolic health support (anecdotal)
- general recovery and resilience interest (anecdotal)
- common biohacker curiosity due to community reports
- interest in mechanisms suggested by early evidence
- used in goal-based stacking discussions (anecdotal)
- exploration in wellness communities despite evidence limits
Use cases (real-world)
These are the most common real-world reasons people look into this peptide, plus the context that tends to matter most (quality, expectations, and safety).
fat-loss interest driven by early mechanistic claims
metabolic curiosity in wellness communities (evidence limited)
often discussed in weight-management stacking conversations (anecdotal)
AOD-9604 is discussed for fat-loss and metabolic goals. Human outcomes are not well-established, so real-world expectations should be conservative.
Common reasons people consider it
- fat-loss interest driven by early mechanistic claims
- metabolic curiosity in wellness communities (evidence limited)
- often discussed in weight-management stacking conversations (anecdotal)
Most commonly reported downsides
- headache
- nausea or stomach upset
- sleep disruption in sensitive users
Rare but important symptoms to watch for
These are uncommon, but if they occur, stop and seek medical care.
- chest pain, fainting, or severe shortness of breath
- severe allergic reaction symptoms (hives, facial swelling, trouble breathing)
Who should be cautious
- people with diabetes or unstable blood sugar control
- people with cardiovascular disease or uncontrolled blood pressure
- pregnant or breastfeeding individuals
- adolescents (developmental risk plus limited evidence)
Interactions summarize known or plausible ways this peptide may intersect with medications, supplements, or physiologic states. Use this as a risk-awareness map: what to ask about, what to watch for, and what deserves a clinician conversation.
Interaction summary
Interactions here are category flags — they’re meant to help you ask better questions and avoid obvious conflicts. They are not a dosing guide.
Drug-class flags to review:
diabetes-glucose-lowering
If you’re on cardiovascular, anticoagulant/antiplatelet, serotonergic, or immunomodulating meds/supplements, treat uncertainty as a reason to slow down and verify with a clinician.
Medication classes
Supplement classes
None
Other peptides
None
Use during adolescence may interfere with normal endocrine signaling and metabolic regulation. Long-term developmental effects have not been studied and may be irreversible.
PUBMED · Grade: human_interventional · Year: 2004
A double-blind, placebo-controlled study of AOD-9604 for obesity
Human trial evaluating weight-loss effects and safety over 12 weeks.
PUBMED · Year: 2002
Lipolytic domain of human growth hormone
Identified the 176–191 fragment responsible for fat metabolism signaling.
AOD-9604 is not approved for human therapeutic use. Despite this, it is widely marketed and consumed as a research peptide, particularly in weight-loss contexts. No regulatory body currently authorizes it for medical treatment. Not FDA-approved for human therapeutic use; widely sold as research-grade peptide.
Pep-Talk is informational only and not medical advice. We make no warranties and are not liable for actions you take. You are responsible for your decisions and outcomes.
Community notes
Educational discussion only. No dosing, protocols, schedules, or instructions. Submissions are moderated before appearing.
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